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Compact CRISPR system unlocks targeted in-body gene editing, with up to 90% efficiency
- April 13, 2026 at 11:20 PM
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A research team has discovered an enhanced CRISPR gene-editing system that could enable targeted delivery inside the human body—a key step toward broader clinical use. Researchers identified a naturally occurring enzyme, Al3Cas12f, that is small enough to fit into adeno-associated virus vectors, a leading targeted delivery method for gene therapies. They then engineered an enhanced version that dramatically improved gene-editing performance in human cells.
Originally published at Phys.org