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Disrupting genome architecture selectively impairs developmental genes
- April 13, 2026 at 9:10 PM
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Weill Cornell Medicine researchers have found that temporarily disabling a protein complex that organizes DNA into loops inside the cell's nucleus drastically disrupted the three-dimensional structure of the genome, but surprisingly, most genes continued to function as usual. However, they also discovered a small group of affected genes that play a critical role in guiding cells to become specific types, for example, heart, brain, or liver cells.
Originally published at Phys.org