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Researchers clarify how cells remove damaged endoplasmic reticulum
- April 7, 2026 at 9:30 PM
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The cell's endoplasmic reticulum (ER) plays a central role in protein synthesis, folding, and calcium (Ca²⁺) storage. When damaged, ER-phagy (self-eating) removes affected ER regions via double-membrane vesicles called autophagosomes. However, the mechanisms underlying its initiation, signaling, and membrane origin had previously been unclear.
Originally published at Phys.org