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Iron catalyst drives asymmetric 1,6 addition of aliphatic Grignard reagents to α,β,γ,δ-unsaturated carbonyl compounds
- February 2, 2026 at 9:08 PM
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Scientists at the Institute of Science Tokyo (Science Tokyo) have successfully realized the highly selective asymmetric 1,6 addition of aliphatic Grignard reagents to α,β,γ,δ-unsaturated carbonyl compounds. This new methodology employs an iron catalyst in combination with a chiral N-heterocyclic carbene ligand, which suppresses undesired side reactions and drives highly regio-, stereo-, and enantioselective alkyl migration.
Originally published at Phys.org