Chemo-optogenetic tool uses vitamin B₁₂ and green light to precisely regulate cell communication

Researchers at The Hong Kong University of Science and Technology (HKUST) have developed CarGAP, a chemo-optogenetic tool that uses vitamin B₁₂ and green light to precisely control gap junctions, the microscopic channels enabling direct cell-to-cell communication. This innovation allows on-demand closing and opening of these intercellular bridges, providing unprecedented spatiotemporal control over vital molecules and electrical signals. Demonstrated in both mammalian cells and living fruit flies, CarGAP provides a powerful new way to study development, immunity, and neural activity, with far-reaching potential for understanding disease mechanisms and advancing regenerative medicine.