Particle-by-particle tracking reveals uneven nanoparticle drug release

Precision medicine aims to transport therapeutic agents, such as molecules, proteins or RNA, to the exact place where they need to act within the body. One of the most promising strategies is the use of nanocarriers: nanoparticles capable of encapsulating the drug, protecting it, transporting it and releasing it in a controlled manner where it is needed. At present, however, their behavior is usually analyzed using techniques based on average measurements of large populations, which conceal the differences between individual particles.