AI-designed proteins enable a new generation of RNA transporters

RNA-based therapeutics use RNA as a blueprint that enables cells to produce specific proteins—including proteins that can precisely modify genes. For this to work, the RNA must reach the inside of the cell intact. Delivery systems currently used for this purpose include virus-derived vehicles and lipid nanoparticles, tiny particles made of fat-like molecules. Both approaches have limitations. Researchers are therefore working on new mechanisms that can deliver RNA into cells more efficiently and, in the future, more selectively.