Tuesday, July 28, 2026
Science

PlasmoBridge chip enables ultrasensitive and rapid monitoring of methotrexate

A research team led by Prof. Wang Hongzhi from the Hefei Institute of Physical Science of the Chinese Academy of Sciences has developed a dual-functional sensor chip called PlasmoBridge, which bridges plasmonic nanoparticles using aptamer molecules. This innovative chip enables ultrasensitive, highl...

PlasmoBridge chip enables ultrasensitive and rapid monitoring of methotrexate
Image: Phys.org
A research team led by Prof. Wang Hongzhi from the Hefei Institute of Physical Science of the Chinese Academy of Sciences has developed a dual-functional sensor chip called PlasmoBridge, which bridges plasmonic nanoparticles using aptamer molecules. This innovative chip enables ultrasensitive, highly specific, and reproducible detection of methotrexate (MTX) in serum, providing a new and feasible strategy for rapid therapeutic drug monitoring (TDM) in clinical settings.

Originally published at Phys.org

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