Newly identified protein interaction helps keep cells' recycling system in balance

Cornell researchers have discovered a new way cells regulate how they respond to stress, identifying an interaction between two proteins that helps keep a critical cellular recycling system in balance. The findings show that a protein called SHKBP1 regulates another protein, p62, which plays a key role in clearing damaged cell components and activating antioxidant defenses. By helping maintain this balance, SHKBP1 allows cells to respond appropriately to stress—a process that can break down in diseases such as cancer and neurodegenerative disorders.