Gut bacteria-derived metabolite extends the lifespan of fruit flies

Gut microbiota influence multiple aspects of host physiology, including metabolic and immune functions. Many metabolites produced by gut bacteria can cross the intestinal epithelium (which the bacteria may not be able to cross) and enter host tissues, providing a pathway through which microbial activity can influence host physiology. However, determining the specific contribution of individual gut bacterial metabolites to host lifespan has remained challenging.