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Secondary silylium ion drives one-pot ketone sulfonamidation, reaching 95% yields
- June 8, 2026 at 3:00 PM
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A research team has developed a novel organocatalysis method based on a silylium Lewis acid. This technology employs an ion-pair catalyst combining a diethylsilylium ion with a weakly coordinating anion, enabling the direct installation of sulfonamide groups into functionalized ketone compounds, including β-ketoesters, which had previously been difficult to react using conventional catalytic methods.
Originally published at Phys.org